HCPs should offer vaginal estrogen therapy to improve genitourinary and sexual symptoms.	STRONG ⊕◯◯◯
Women with POI may be offered vaginal estrogen therapy if genitourinary symptoms are not fully relieved by using systemic HT.	CONDITIONAL ⊕◯◯◯
Vaginal lubricants and moisturizers can be used for treatment of vaginal discomfort and dyspareunia in women with POI and can be combined with other treatments.	CONDITIONAL ⊕◯◯◯
The guideline group currently does not recommend laser or thermal energy as standard care for genitourinary symptoms due to inconclusive evidence of benefit from RCTs.	GPP