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. 2024 Dec 9;2024(4):hoae065. doi: 10.1093/hropen/hoae065
HCPs and women should be aware that POI is associated with an increased risk of cognitive impairment and dementia.
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The possible detrimental effect on cognition and increased risk of dementia, parkinsonism, and other neurologic diseases should be discussed when planning bilateral oophorectomy under the age of 45 years, especially for women at an average risk of ovarian cancer. 
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