HT is recommended in women with POI until the usual age of menopause to reduce the possible risk of cognitive impairment and dementia.	STRONG ⊕⊕◯◯
HT may be recommended in women with POI to protect neurological function even in the absence of menopausal symptoms.	CONDITIONAL ⊕⊕◯◯
The guideline group recommends that women with POI should be encouraged to adopt a healthy lifestyle (including physical activity, healthy diet, avoiding smoking, and maintaining normal body weight) to reduce the risk of cognitive impairment and dementia.	GPP