Puberty should be induced or progressed with estradiol, starting with low dose at the age of 11 years with a gradual increase over 2–3 years.	STRONG ⊕⊕◯◯
In cases of late diagnosis and for those girls in whom growth is not a concern, HCPs can consider a modified regimen of estradiol therapy.	CONDITIONAL ⊕◯◯◯
Evidence for the optimum mode of administration (oral or transdermal) is inconclusive. HCPs may prefer transdermal estradiol as it results in more physiological estrogen concentrations.	CONDITIONAL ⊕◯◯◯
A combined oral contraceptive should not be used for puberty induction.	STRONG ⊕◯◯◯
The guideline group recommends starting cyclical progestogens after ∼2 years of estrogen therapy or when breakthrough bleeding occurs.	GPP