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. 2024 Nov 25;56(12):2790–2803. doi: 10.1038/s41588-024-01999-x

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 4 — a Signs of active mutational processes at chromosome 20 in CK282 displayed by varying breakpoints of the terminal deletion at 20q in representative cells. Reads mapped to the Watson (orange) or Crick (green) strand. The terminal deletion breakpoints are annotated above the ideogram in red and interstitial deletion breakpoints in grey. b Stacked barplot showing the cell fraction of different structural variants detected at chromosome 20 in the different subclones in CK282 at diagnosis. The number of cells in each subclone is indicated on top of the bar and the type of structural variant with the corresponding breakpoint(s) labelled on the right. (*, additional complex rearrangement at 20p). c Strand-specific read depth of representative single cells from CK349 showing signs of active mutational processes at chromosome 17. d Stacked barplot showing the cell fraction of different terminal deletions detected at chromosome 17 in the different subclones in CK349 at diagnosis. The number of cells in each subclone is indicated on top of the bar and the terminal deletion with the corresponding breakpoint labelled on the right. Chr: Chromosome, SV: Structural variant, Del: Deletion, Inv: Inversion.