Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2024 Nov 25;56(12):2790–2803. doi: 10.1038/s41588-024-01999-x

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Extended Data Fig. 5 — a Strand-specific read depth of all single cells from CK349 showing differing amplification signals at chromosome 11 representing seismic amplifications, and a representative cell with a normal chromosome 11 (top, major clone). Reads denoting somatic structural variants, discovered using scTRIP, mapped to the Watson (W; orange) or Crick (C; green) strand. Grey: single cell IDs. b Strand-specific read depth of seismic amplification (left) separated into read depth and phase (right) of a representative CK349 cell. Reads overlapping single nucleotide polymorphisms were assigned to haplotypes H1 (red lollipops) or H2 (blue lollipops). Grey: single cell ID. c Multiplex fluorescence in situ hybridization (M-FISH) of a cell with normal chromosome 11 and a linearized marker chromosome containing segments from chromosome 15, 13, 11 and Y obtained from the secondary patient-derived xenograft (PDX) of CK349. Chr: Chromosome, InvDup: Inverted Duplication, Del: Deletion, Ter: Terminal, t: Translocation.