Figure 2.
Molecular features of ESC-derived iNK and CD19 CAR-UiNK cells. (A) Projection of iNK and CD19 CAR-UiNK cells (left). UMAP visualization of iNK and CD19 CAR-UiNK cells respectively (right). (B) Violin plots showing the expression profiles of indicated NK cell-surface receptors and effectors (CD244, CD226, KLRK1, NCR3, NCR1, KLRD1, CD96, KLRC1, CD69, TNFSF10, GZMB, and PRF1) in iNK and CD19 CAR-UiNK cells. One point represents one cell. (C) Flow cytometry analysis of the expression levels of NK cell receptors and effectors (2B4, DNAM-1, NKG2D, NKp30, NKp46, CD94, CD96, NKG2A, CD69, TARIL, GzmB, and Perforin).