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. 2024 Nov 27;15:1504459. doi: 10.3389/fimmu.2024.1504459

Figure 4.

Figure 4

The expression of IFN-γ, TNF-α, and CD107a by iNK and CD19 CAR-UiNK cells upon stimulation with Nalm-6 tumor cells. (A, B) Measurement of IFN-γ production by iNK or CD19 CAR-UiNK cells in response to Nalm-6 tumor cells. The iNK or CD19 CAR-UiNK cells were stimulated by Nalm-6 at the ratio of 0.5:1 for 4 hours. Data are represented as means ± SD (n=3). NS, not significant, ***P < 0.001 (Two-tailed independent t-test). (C, D) Evaluation of TNF-α production by iNK or CD19 CAR-UiNK cells in response to Nalm-6 tumor cells. The iNK or CD19 CAR-UiNK cells were stimulated by Nalm-6 at the ratio of 0.5:1 for 4 hours. Data are represented as means ± SD (n=3). NS, not significant, **P < 0.01 (Two-tailed independent t-test). (E, F) Assessment of CD107a expression by iNK or CD19 CAR-UiNK cells following 4 hours of co-culture with Nalm-6 tumor cells at the ratio of 0.5:1. Data are represented as means ± SD (n=3). NS, not significant, ***P < 0.001 (Two-tailed independent t-test).