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. 2024 Nov 27;18:1506352. doi: 10.3389/fnins.2024.1506352

Figure 5.

Figure 5

Effects of PEA injection on levels of select lipids in the plasma and CNS. (A) Levels of PEA in plasma 30 min after vehicle, 3, 10, and 30 mg/kg PEA i.p. injection. (B) PEA levels (moles/gram tissue) in 6 brain regions (hypothalamus, HYP; cerebellum, CER; striatum (caudate/putamen), STR; thalamus, THAL; anterior frontal cortex, CTX; hippocampus, HIPP) 30 min after vehicle (white bars) and 30 mg/kg PEA injection (red bars). (C–H) Show the levels of the following endogenous lipids in those same 6 brain regions 30 min after vehicle and 30 mg/kg PEA injection: (C) Anandamide (AEA), (D) 2-arachidonoyl glycerol (2-AG), (E) N-arachidonoyl Gamma-aminobutyric acid (A-GABA); (F) Arachidonic Acid (AA); (G) N-palmitoyl serine (Pal-Ser); and (H) N-oleoyl alanine. #p < 0.1–0.051; *p < 0.05; **p < 0.01, ***and ****p < 0.001, ns = not significant.