Figure 5.
Effects of PEA injection on levels of select lipids in the plasma and CNS. (A) Levels of PEA in plasma 30 min after vehicle, 3, 10, and 30 mg/kg PEA i.p. injection. (B) PEA levels (moles/gram tissue) in 6 brain regions (hypothalamus, HYP; cerebellum, CER; striatum (caudate/putamen), STR; thalamus, THAL; anterior frontal cortex, CTX; hippocampus, HIPP) 30 min after vehicle (white bars) and 30 mg/kg PEA injection (red bars). (C–H) Show the levels of the following endogenous lipids in those same 6 brain regions 30 min after vehicle and 30 mg/kg PEA injection: (C) Anandamide (AEA), (D) 2-arachidonoyl glycerol (2-AG), (E) N-arachidonoyl Gamma-aminobutyric acid (A-GABA); (F) Arachidonic Acid (AA); (G) N-palmitoyl serine (Pal-Ser); and (H) N-oleoyl alanine. #p < 0.1–0.051; *p < 0.05; **p < 0.01, ***and ****p < 0.001, ns = not significant.