Table 1.
Negative volume in BOLD signal.
| Vehicle | 3 mg/kg | 10 mg/kg | 30 mg/kg | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Brain area | Ave | SE | Ave | SE | Ave | SE | Ave | SE | P val | Ω Sq |
| Posterior thalamus | 2 | 1.5 | 74 | 13.4 | 85 | 5.3 | 43 | 13.2 | 0.005 | 0.515 |
| CA2 | 1 | 0.5 | 4 | 0.6 | 6 | 0.7 | 3 | 0.7 | 0.006 | 0.664 |
| Ventral medial striatum | 1 | 0.3 | 97 | 6.0 | 70 | 15.0 | 52 | 17.0 | 0.006 | 0.664 |
| Red n. | 0 | 0.0 | 7 | 1.8 | 9 | 0.9 | 4 | 1.3 | 0.006 | 0.632 |
| Parafascicular thalamus | 1 | 0.5 | 40 | 9.9 | 50 | 8.2 | 25 | 8.6 | 0.007 | 0.572 |
| Accumbens core | 7 | 3.0 | 78 | 7.9 | 62 | 13.3 | 32 | 9.3 | 0.007 | 0.590 |
| Retrosplenial rostral ctx | 6 | 6.0 | 79 | 7.3 | 60 | 6.9 | 41 | 13.1 | 0.007 | 0.609 |
| Reticular n. midbrain | 18 | 6.0 | 161 | 38.4 | 150 | 11.2 | 74 | 27.1 | 0.008 | 0.456 |
| Dorsal medial striatum | 4 | 2.2 | 160 | 10.1 | 125 | 21.6 | 93 | 33.3 | 0.010 | 0.529 |
| Dorsal lateral striatum | 1 | 0.6 | 220 | 25.1 | 196 | 28.6 | 135 | 41.4 | 0.012 | 0.583 |
| Dentate gyrus ventral | 13 | 6.2 | 53 | 7.1 | 54 | 8.9 | 24 | 11.1 | 0.013 | 0.521 |
| Claustrum | 3 | 1.1 | 21 | 2.9 | 20 | 4.3 | 11 | 4.0 | 0.013 | 0.572 |
| Prelimbic ctx | 1 | 0.3 | 95 | 13.1 | 71 | 21.9 | 51 | 19.0 | 0.013 | 0.530 |
| Ventral posteromedial thalamus | 0 | 0.0 | 41 | 9.7 | 39 | 7.8 | 25 | 7.1 | 0.013 | 0.418 |
| Anterior pretectal n. | 1 | 1.3 | 19 | 2.3 | 22 | 1.9 | 12 | 5.1 | 0.014 | 0.565 |
| Lateral posterior thalamus | 3 | 3.0 | 52 | 11.2 | 53 | 8.1 | 30 | 13.6 | 0.014 | 0.451 |
| Dentate gyrus dorsal | 5 | 3.3 | 82 | 25.1 | 74 | 13.6 | 51 | 14.3 | 0.014 | 0.387 |
| Superior colliculus | 27 | 11.7 | 146 | 32.8 | 143 | 12.0 | 103 | 19.4 | 0.015 | 0.407 |
| Primary motor ctx | 45 | 27.1 | 333 | 44.0 | 259 | 55.6 | 198 | 58.2 | 0.015 | 0.470 |
| Somatosensory ctx jaw | 16 | 7.5 | 173 | 35.4 | 139 | 33.4 | 98 | 26.7 | 0.015 | 0.427 |
| Somatosensory ctx hindlimb | 6 | 6.0 | 81 | 12.3 | 65 | 9.7 | 64 | 13.2 | 0.016 | 0.524 |
| Ventral posteriolateral thalamus | 1 | 0.5 | 42 | 6.2 | 38 | 7.1 | 28 | 6.7 | 0.016 | 0.408 |
| Pontine reticular n. oral | 7 | 2.5 | 54 | 16.3 | 66 | 7.8 | 31 | 12.2 | 0.017 | 0.437 |
| Somatosensory ctx upper lip | 17 | 5.2 | 155 | 38.2 | 134 | 18.9 | 116 | 23.8 | 0.017 | 0.394 |
| Ventrolateral thalamus | 1 | 0.5 | 35 | 8.0 | 40 | 4.3 | 26 | 9.2 | 0.018 | 0.533 |
| Zona incerta | 0 | 0.0 | 32 | 11.5 | 18 | 9.2 | 12 | 4.3 | 0.018 | 0.359 |
| CA1 dorsal | 4 | 2.2 | 137 | 27.0 | 136 | 12.9 | 96 | 28.3 | 0.019 | 0.414 |
| Visual 2 ctx | 15 | 2.9 | 181 | 24.9 | 188 | 7.5 | 146 | 28.6 | 0.019 | 0.436 |
| White matter, anterior | 110 | 16.4 | 526 | 97.8 | 501 | 66.5 | 413 | 57.6 | 0.019 | 0.349 |
| Retrosplenial caudal ctx | 13 | 4.5 | 220 | 24.9 | 187 | 22.5 | 170 | 41.4 | 0.021 | 0.432 |
| Somatosensory ctx barrel field | 7 | 3.2 | 223 | 55.4 | 210 | 28.1 | 174 | 47.2 | 0.021 | 0.428 |
| Parietal ctx | 3 | 2.5 | 66 | 13.0 | 69 | 12.7 | 56 | 15.6 | 0.022 | 0.531 |
| Temporal ctx | 24 | 9.7 | 55 | 2.8 | 46 | 3.0 | 43 | 4.7 | 0.023 | 0.418 |
| Ventral orbital ctx | 16 | 6.2 | 63 | 5.2 | 61 | 8.3 | 29 | 12.8 | 0.023 | 0.392 |
| Bed n. stria terminalis | 0 | 0.0 | 31 | 3.4 | 28 | 11.7 | 22 | 10.7 | 0.024 | 0.469 |
| Somatosensory ctx forelimb | 12 | 11.2 | 135 | 24.9 | 113 | 19.1 | 90 | 26.6 | 0.024 | 0.433 |
| Ventral lateral striatum | 19 | 5.9 | 212 | 37.6 | 197 | 35.5 | 163 | 37.2 | 0.024 | 0.419 |
| Visual 1 ctx | 4 | 2.1 | 153 | 24.2 | 163 | 19.6 | 134 | 30.8 | 0.024 | 0.369 |
| Somatosensory ctx trunk | 0 | 0.3 | 12 | 3.2 | 13 | 3.8 | 10 | 2.3 | 0.025 | 0.483 |
| Reticular n. | 0 | 0.3 | 31 | 9.4 | 32 | 5.2 | 26 | 6.8 | 0.026 | 0.374 |
| 4th cerebellar lobule | 54 | 4.6 | 95 | 13.7 | 97 | 8.1 | 53 | 21.2 | 0.026 | 0.355 |
| White matter, posterior | 8 | 3.9 | 69 | 23.6 | 74 | 8.0 | 51 | 18.4 | 0.026 | 0.390 |
| CA3 hippocampus ventral | 7 | 4.8 | 33 | 6.9 | 33 | 7.1 | 15 | 6.9 | 0.026 | 0.426 |
| Globus pallidus | 0 | 0.0 | 18 | 2.3 | 12 | 6.2 | 12 | 3.1 | 0.027 | 0.470 |
| Lateral septal n. | 6 | 5.8 | 115 | 27.9 | 93 | 25.9 | 82 | 32.8 | 0.028 | 0.391 |
| Anterior thalamic nuclei | 4 | 2.8 | 39 | 7.8 | 36 | 4.2 | 27 | 10.0 | 0.030 | 0.446 |
| Extended amygdala | 0 | 0.0 | 10 | 3.1 | 5 | 2.0 | 4 | 1.4 | 0.030 | 0.395 |
| Secondary somatosensory ctx | 12 | 6.6 | 97 | 26.6 | 111 | 10.7 | 94 | 13.2 | 0.030 | 0.322 |
| Central amygdaloid n. | 6 | 3.8 | 40 | 9.1 | 41 | 4.3 | 18 | 10.5 | 0.031 | 0.399 |
| Ventral anterior thalamus | 1 | 0.5 | 16 | 3.3 | 15 | 1.4 | 9 | 3.9 | 0.032 | 0.461 |
| Infralimbic ctx | 3 | 1.7 | 43 | 11.2 | 32 | 4.3 | 25 | 10.0 | 0.032 | 0.346 |
| Medial dorsal thalamus | 1 | 1.0 | 16 | 4.3 | 20 | 4.4 | 13 | 5.8 | 0.035 | 0.452 |
| CA1 hippocampus ventral | 26 | 12.8 | 94 | 5.1 | 74 | 12.9 | 44 | 21.3 | 0.035 | 0.357 |
| Lateral geniculate | 0 | 0.3 | 20 | 11.1 | 14 | 3.2 | 15 | 4.1 | 0.036 | 0.288 |
| Subiculum dorsal | 2 | 1.3 | 33 | 8.1 | 33 | 5.2 | 27 | 8.7 | 0.038 | 0.303 |
| Raphe linear | 0 | 0.0 | 9 | 3.5 | 8 | 1.5 | 4 | 2.0 | 0.038 | 0.372 |
| Lateral orbital ctx | 20 | 8.4 | 122 | 20.0 | 101 | 23.2 | 50 | 25.2 | 0.039 | 0.360 |
| Insular ctx | 123 | 10.1 | 295 | 81.5 | 317 | 44.8 | 247 | 34.8 | 0.039 | 0.362 |
| Perirhinal ctx | 43 | 18.9 | 98 | 17.1 | 103 | 8.3 | 57 | 20.2 | 0.040 | 0.329 |
| Somatosensory ctx shoulder | 2 | 2.3 | 18 | 1.2 | 13 | 3.5 | 14 | 3.2 | 0.040 | 0.434 |
| CA3 dorsal | 10 | 5.9 | 70 | 22.9 | 68 | 10.8 | 57 | 17.1 | 0.042 | 0.310 |
| Anterior cingulate area | 20 | 15.5 | 167 | 36.0 | 151 | 32.9 | 136 | 31.7 | 0.043 | 0.344 |
| Locus coeruleus | 0 | 0.3 | 0 | 0.0 | 2 | 0.6 | 1 | 0.4 | 0.043 | 0.417 |
| 6th cerebellar lobule | 74 | 13.4 | 91 | 28.5 | 146 | 8.2 | 88 | 32.2 | 0.044 | 0.354 |
| Auditory ctx | 52 | 20.5 | 196 | 57.9 | 232 | 11.9 | 172 | 31.8 | 0.045 | 0.322 |
| Reuniens n. | 0 | 0.0 | 14 | 5.2 | 15 | 6.9 | 11 | 4.1 | 0.045 | 0.394 |
| Ventromedial thalamus | 0 | 0.0 | 28 | 7.9 | 25 | 7.1 | 16 | 5.8 | 0.046 | 0.330 |
| Pontine reticular n. caudal | 29 | 11.5 | 81 | 30.0 | 109 | 11.8 | 50 | 19.9 | 0.047 | 0.239 |
| Triangular septal n. | 0 | 0.0 | 5 | 1.9 | 3 | 1.1 | 4 | 1.5 | 0.047 | 0.412 |
| Caudal piriform ctx | 61 | 8.1 | 135 | 25.5 | 134 | 9.7 | 95 | 21.6 | 0.050 | 0.302 |