. 2024 Aug 23;50(2):362–371. doi: 10.1038/s41386-024-01972-6

Table 1.

Mean values and statistics for the acute subjective effects of MDMA, S-MDMA, R-MDMA and placebo.

		Placebo	125 mg R-MDMA	250 mg R-MDMA	125 mg MDMA	125 mg S-MDMA	F_{4, 92}	P=	Pla - R-MDMA (125 mg)	Pla - R-MDMA (250 mg)	Pla - MDMA	Pla - S-MDMA	R-MDMA (125 mg) - R-MDMA (250 mg)	R-MDMA (125 mg) - MDMA	R-MDMA (125 mg) - S-MDMA	R-MDMA (250 mg) - MDMA	R-MDMA (250 mg) - S-MDMA	MDMA - S-MDMA
		Mean ± SEM	Mean ± SEM	Mean ± SEM	Mean ± SEM	Mean ± SEM	F_{4, 92}	P=	Pla - R-MDMA (125 mg)	Pla - R-MDMA (250 mg)	Pla - MDMA	Pla - S-MDMA	R-MDMA (125 mg) - R-MDMA (250 mg)	R-MDMA (125 mg) - MDMA	R-MDMA (125 mg) - S-MDMA	R-MDMA (250 mg) - MDMA	R-MDMA (250 mg) - S-MDMA	MDMA - S-MDMA
Visual Analog Scale (VAS, %max)
Unidirectional scales (0–100)
Any drug effect	ΔE_max	4.8 ±2.1	42 ±7.3	66 ±6.1	77 ±5.3	90 ±3.1	68.92	<0.001	***	***	***	***	***	***	***	NS	**	NS
Good drug effect	ΔE_max	7.9 ±4.1	43 ±7.1	68 ±6.6	78 ±5.1	90 ±3.8	54.97	<0.001	***	***	***	***	***	***	***	NS	**	NS
Bad drug effect	ΔE_max	0.5 ±0.3	14 ±5.1	19 ±4.6	20 ±5.9	39 ±7.0	10.51	<0.001	NS	*	*	***	NS	NS	***	NS	*	*
I like the effect	ΔE_max	7.7 ±3.8	47 ±7.1	68 ±6.6	81 ±5.0	91 ±3.6	60.12	<0.001	***	***	***	***	**	***	***	NS	**	NS
Stimulated	ΔE_max	2.5 ±1.1	31 ±6.9	60 ±6.7	70 ±6.7	88 ±3.7	58.82	<0.001	***	***	***	***	***	***	***	NS	***	NS
Drug high	ΔE_max	1.4 ±0.6	29 ±7.0	48 ±7.6	73 ±6.7	84 ±5.1	49.31	<0.001	***	***	***	***	*	***	***	**	***	NS
Fear	ΔE_max	0.0 ±0.0	4.9 ±4.2	5.8 ±3.4	5.9 ±3.4	19 ±6.9	3.90	0.006	NS	NS	NS	**	NS	NS	*	NS	NS	NS
Alteration of vision	ΔE_max	3.0 ±1.6	24 ±6.9	37 ±6.7	54 ±7.8	74 ±6.7	32.23	<0.001	*	***	***	***	NS	***	***	NS	***	*
Alteration of sense of time	ΔE_max	2.2 ±2.0	28 ±7.2	46 ±7.7	60 ±6.8	73 ±6.6	34.55	<0.001	**	***	***	***	NS	***	***	NS	**	NS
Audio-visual synesthesia	ΔE_max	4.6 ±4.2	15 ±5.9	31 ±6.8	29 ±6.8	53 ±8.3	16.01	<0.001	NS	**	**	***	NS	NS	***	NS	**	**
Ego dissolution	ΔE_max	1.5 ±0.8	22 ±7.4	32 ±7.4	41 ±7.7	58 ±8.2	17.83	<0.001	*	***	***	***	NS	NS	***	NS	**	NS
Bidirectional scales (−50 to 50)
Happy	ΔE_max	3.9 ±2.2	14 ±3.5	24 ±3.8	34 ±3.3	38 ±3.4	32.25	<0.001	*	***	***	***	NS	***	***	*	***	NS
Content	ΔE_min	4.8 ±2.2	19 ±3.4	30 ±3.6	39 ±2.8	44 ±2.5	46.83	<0.001	***	***	***	***	*	***	***	*	***	NS
Talkative	ΔE_max	2.8 ±1.6	13 ±3.2	22 ±3.9	35 ±3.6	37 ±3.9	30.55	<0.001	NS	***	***	***	NS	***	***	**	**	NS
Open	ΔE_max	4.3 ±2.3	15 ±3.4	28 ±3.9	40 ±2.9	42 ±2.9	50.64	<0.001	*	***	***	***	**	***	***	**	***	NS
Trust	ΔE_max	4.0 ±2.0	16 ±3.5	24 ±4.1	40 ±3.1	44 ±2.3	48.93	<0.001	**	***	***	***	NS	***	***	***	***	NS
I feel close to others	ΔE_max	0.8 ±0.4	14 ±3.1	23 ±3.9	34 ±3.3	41 ±3.4	43.83	<0.001	**	***	***	***	NS	***	***	**	***	NS
I want to be alone	ΔE_max	0.2 ±0.2	6.1 ±2.6	10 ±3.4	6.9 ±2.7	12 ±3.4	4.15	0.004	NS	*	NS	**	NS	NS	NS	NS	NS	NS
I want to be with others	ΔE_max	1.8 ±1.1	17 ±3.4	24 ±4.0	31 ±3.5	40 ±3.5	32.15	<0.001	***	***	***	***	NS	**	***	NS	***	NS
Autonomic effects
Systolic blood pressure (mmHg)	E_max	127 ±2.7	138 ±2.5	147 ±2.5	152 ±2.3	160 ±3.1	74.46	<0.001	***	***	***	***	***	***	***	NS	***	**
Diastolic blood pressure (mmHg)	E_max	78 ±0.8	84 ±1.1	91 ±1.6	92 ±1.3	97 ±1.6	62.90	<0.001	***	***	***	***	***	***	***	NS	***	***
Mean arterial pressure (mmHg)	E_max	94 ±1.0	101 ±1.4	108 ±1.8	111 ±1.3	117 ±1.9	93.43	<0.001	***	***	***	***	***	***	***	NS	***	***
Heart rate (beats/min)	E_max	75 ±1.3	87 ±2.6	93 ±3.4	95 ±3.5	100 ±3.3	21.50	<0.001	***	***	***	***	NS	NS	***	NS	NS	NS
Rate pressure product (mmHg x bpm)	E_max	9135 ±218	11565 ±476	12999 ±569	14018 ±662	15389 ±705	41.15	<0.001	***	***	***	***	NS	***	***	NS	***	NS
Body temperature (°C)	E_max	37.1 ±0.06	37.4 ±0.09	37.5 ±0.09	37.6 ±0.08	37.7 ±0.10	10.25	<0.001	NS	***	***	***	NS	NS	*	NS	NS	NS
List of complaints (LC score)
Acute adverse effects	0–9 h	0.5 ±0.5	9.4 ±1.8	14 ±1.9	10 ±1.7	13 ±1.5	21.58	<0.001	***	***	***	***	NS	NS	NS	NS	NS	NS
Subacute adverse effects	9–24 h	0.1 ±0.5	6.7 ±1.9	8.2 ±1.5	5.4 ±1.3	7.2 ±1.4	8.95	<0.001	***	***	**	***	NS	NS	NS	NS	NS	NS
Subacute adverse effects	24–72 h	1.3 ±0.7	6.9 ±1.8	6.0 ±1.7	5.1 ±1.6	10 ±2.2	6.05	<0.001	*	NS	NS	***	NS	NS	NS	NS	NS	NS
Becks depression-inventar (BDI)
BDI Score	24–72 h	2.0 ±0.9	4.3 ±1.2	4.4 ±1.2	4.8 ±1.3	8.4 ±1.7	4.07	0.004	NS	NS	NS	*	NS	NS	NS	NS	NS	NS
Symptom checklist 90 R (SCL-90-R)
GSI score	24–72 h	0.08 ±0.02	0.18 ±0.05	0.17 ±0.05	0.14 ±0.03	0.34 ±0.77	5.02	0.001	NS	NS	NS	*	NS	NS	NS	NS	NS	NS
Hormones and markers
Oxytocin (pg/mL)^α	ΔC_max	2.9 ±1.9	48 ±13	178 ±22	296 ±33	436 ±40	66.2^β	<0.001	NS	***	***	***	***	***	***	**	***	***
Cortisol (nmol/L)	ΔC_max	−156 ±27	140 ±28	249 ±26	285 ±26	398 ±27	81.90	<0.001	***	***	***	***	**	**	***	NS	***	*
Prolactin (µg/L)	ΔC_max	−6.5 ±2.0	13 ±4.5	35 ±5.5	39 ±7.1	53 ±8.5	32.20	<0.001	***	***	***	***	***	**	***	NS	NS	**

NS not significant, ΔE_max maximal effect difference from baseline, ΔC_max maximal plasma concentrationfrom baseline, N = 24, αN = 20, β = F_4,81.

*P < 0.05; **P < 0.01; ***P < 0.001.