TABLE 2.

Subgroup analysis of the primary outcome of overall prevalence of fatigue.

Subgroup	No. of studies	No. of participants enrolled	Prevalence (%)	95% CI (%)	I 2 (%)	p Value for subgroup difference
Study type						0.40
Cross‐sectional	8	872	69	57–81	94
Prospective cohort	15	1584	72	63–80	93
Phase 3 RCT	3	243	87	64–100	89
Setting						0.02
Inpatient	5	293	83	66–99	90
Outpatient	3	140	55	44–66	41
Both inpatient and outpatient	15	2077	69	61–77	93
Type of cancer						0.58
Mixed cancer types	19	1905	70	62–79	95
Hematological malignancies	5	714	79	65–93	97
CNS tumors	2	80	77	47–100	89
Type of cancer treatment						0.38
Chemotherapy	11	1096	78	68–89	95
Chemotherapy/Surgery/Radiation	4	475	68	47–89	98
Type of fatigue scale						0.48
Childhood Fatigue Scale	4	185	75	50–99	95
Memorial Symptom Assessment Scale	5	365	72	60–84	88
Symptom Screening in Pediatrics Tool	2	205	55	39–71	76
PROMIS Fatigue Subscale	4	1029	64	55–73	87
PedsQL Multidimensional Fatigue Scale	4	411	69	52–87	94
Person reporting fatigue						0.33
Parent/Caregiver	4	415	77	64–90	81
Patient	17	1711	69	60–78	96
Patient and parent/Caregiver	5	573	81	66–95	95
Adequate sample frame						0.95
Yes	11	1751	71	64–79	91
Unclear	12	829	73	61–86	97
No	3	119	73	45–100	94
Adequate sampling						0.78
Yes	11	1033	73	64–83	92
Unclear	11	1206	74	63–85	97
No	4	460	66	45–87	97
Adequate response rate						0.90
Yes	17	1388	74	65–83	96
Unclear	3	425	71	42–100	98
No	6	886	71	61–80	88

Abbreviations: CI, confidence interval; CNS, central nervous system; PedsQL, Pediatric Quality of Life; PROMIS, Patient‐Reported Outcomes Measurement Information System; RCT, randomized controlled trial.