Skip to main content
. 2024 Nov 5;30(69):e202402866. doi: 10.1002/chem.202402866

Scheme 2.

Scheme 2

Synthesis of precursors 2 and 3. Conditions: a) Pd(PPh3)4; Na2CO3; Tol/MeOH/H2O (4 : 1 : 1.5); 80 °C; 5 h; 65 %. b) p‐TsOH; NaNO2; KI; ACN/H2O (3 : 1); 0 °C‐r.t.; 16 h; 90 %. c) NaOH; MeOH/H2O; reflux; 3 h; 98 %. d) 7’; CsF; DMF; r.t.; 16 h; 99 % e) H2SO4; MeOH; reflux; 4 h; 85 % f) PdCl2(dppf); K2CO3; DME/MeOH/H2O (4 : 1 : 1); 65 °C; 16 h; 71 %. g) PdCl2(dppf); B2Pin2; KOAc; dioxane; 90 °C; 6 h; 85 %. h) LiOH; THF/H2O; r.t.; 1 h; quant. i) PdCl2(dppf); K2CO3; DME/H2O (4 : 1); 60 °C; 3 h; 87 %. j) 14; DCC; DMAP; CH2Cl2/DMF; r.t.; 1.5 h; 44 %. Bottom‐right) Solid‐state structure of 3 plotted as ORTEP plots with 50 % probability.