Table 1.
Comparison of selected baseline characteristics and primary outcomes between younger and older patients.
| Age 18–49 years (n = 1346) | Age ⩾50 years (n = 15305) | Total (n = 16651) | p-Value | |
|---|---|---|---|---|
| Age (years) | 43 (37–47) | 74 (65–82) | 73 (62–81) | <0.001 |
| Men | 802 (59.6) | 8268 (54.0) | 9070 (54.5) | <0.001 |
| Stroke severity (NIHSS) | 7 (4–13) | 8 (5–15) | 8 (5–15) | <0.001 |
| Dependent before stroke (pre-mRS score 3–5) | 14 (1.2) | 1435 (10.6) | 1449 (9.8) | <0.001 |
| Onset-to-treatment time (min) | 140 (100–190) | 148 (105–195) | 147 (105–195) | 0.002 |
| Admission systolic blood pressure (mmHg) | 140 (125–152) | 157 (140–173) | 155 (140–172) | <0.001 |
| Admission glucose (mmol/L) | 6.0 (5.4–6.9) | 6.6 (5.8–8.0) | 6.6 (5.7–8.0) | <0.001 |
| Admission creatinine (µmol/L) | 74 (64–86) | 82 (69–99) | 81 (68–98) | <0.001 |
| Atrial fibrillation | 40 (3.5) | 3896 (28.2) | 3936 (26.3) | <0.001 |
| Hypertension | 325 (24.2) | 11,139 (72.9) | 11,464 (69.0) | <0.001 |
| Current (or stopped <2 years) smoking | 534 (42.0) | 2664 (19.0) | 3198 (20.9) | <0.001 |
| Hypercholesterolemia | 320 (23.8) | 7088 (46.5) | 7408 (44.7) | <0.001 |
| Diabetes | 67 (5.0) | 3158 (20.7) | 3225 (19.4) | <0.001 |
| Coronary artery disease | 72 (5.4) | 2939 (19.3) | 3011 (18.1) | <0.001 |
| Prior ischemic stroke | 93 (6.9) | 2418 (15.8) | 2511 (15.1) | <0.001 |
| Prior antithrombotics, any | 147 (11.2) | 7215 (48.3) | 7362 (45.3) | <0.001 |
| sICH (ECASS2) | 22 (1.6) | 700 (4.6) | 722 (4.3) | <0.001 |
| Death | 31 (2.3) | 2167 (14.2) | 2198 (13.2) | <0.001 |
| Favorable functional outcome* | 1102 (81.9) | 8626 (56.4) | 9728 (58.4) | <0.001 |
| Poor functional outcome† | 190 (16.1) | 3612 (30.9) | 3802 (29.5) | <0.001 |
ECASS indicates European Cooperative Acute Stroke Study; IVT: intravenous thrombolysis; mRS: modified Rankin Scale; NIHSS: National Institutes of Health Stroke Scale; and sICH: symptomatic intracerebral hemorrhage (ECASS II definition).
Data expressed as either n (%) or median (interquartile range). Cohort of 16,651 IVT treated patients aged 18–105 years. Multicenter data collected in the years of 1998–2020.
*
Favorable functional outcome = mRS 3 months score ⩽2.
†
Poor functional outcome = mRS 3 months score 3–5 for patients with prestroke mRS score ⩽2 and mRS score 4–5 for patients with prestroke mRS score >2.