Table 2.

Multivariate analysis on association between age and selected outcome variables.

Age	Favorable functional outcome*	sICH	Death
Age, <50 years versus age ⩾50 years	2.30 (1.80–2.95) p < 0.001†	0.45 (0.23–0.90) p = 0.023‡	0.21 (0.11–0.39) p < 0.001†
Age, 18–29 years versus age 30–49 years	1.82 (0.69–4.77) p = 0.224†	0.38 (0.05–2.89) p = 0.278§	0.57 (0.07–4.36) p = 0.586ǁ

ECASS indicates European Cooperative Acute Stroke Study; IVT: intravenous thrombolysis; mRS: modified Rankin Scale; NIHSS: National Institutes of Health Stroke Scale; and sICH: symptomatic intracerebral hemorrhage (ECASS II definition).

Results are expressed as odds ratio (OR) and 95 % confidence interval (CI). Results are adjusted for all covariates that had a p-value of 0.05 or less in the univariate analysis. Cohort of 16,651 IVT treated patients aged 18–105 years. Multicenter data collected in the years of 1998–2020.

^*Favorable functional outcome = mRS 3 months score ⩽2.

^†Adjusted for: sex, NIHSS on admission, dependent before stroke (mRS 3–5), onset-to-treatment-time, systolic blood pressure on admission, creatinine on admission, glucose on admission, atrial fibrillation, diabetes, hypercholesterolemia, current smoking or stopped within 2 years, prior ischemic stroke, prior antithrombotics, coronary artery disease.

^‡Adjusted for: NIHSS on admission, systolic blood pressure on admission, creatinine on admission, glucose on admission, atrial fibrillation, diabetes, current smoking or stopped within 2 years, prior antithrombotics, coronary artery disease.

^§Adjusted for: NIHSS on admission, prior antithrombotics.

^ǁAdjusted for: NIHSS on admission, prior antithrombotics, atrial fibrillation.