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. 2024 Nov 25;14(1):2432345. doi: 10.1080/22221751.2024.2432345

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© 2024 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group, on behalf of Shanghai Shangyixun Cultural Communication Co., Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.

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Figure 5. — Development of second-generation CAR-T cells from C8 and C10 mAbs. (A) Design of different transgenes encoding for second-generation CAR molecules using two C8 and C10 scFv sequences, and two different costimulatory domains, CD28 and 4-1BB (named C8-28z/C10-28z and C8-BBz/C10-BBz, respectively). (B) Graph shows CAR-T cell proliferation during 10 days after stimulation with CD3/CD28 Dynabeads and IL-2, assessed by flow cytometry. (C) Flow cytometry plots showing CAR surface expression of the different constructs on human T cells.