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. 2024 Dec 10;22(4):15593258241308051. doi: 10.1177/15593258241308051

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© The Author(s) 2024

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 6. — The effects of metformin on intestinal gut microbiota. (A)-(C) The indexes of the abundance and diversity of intestinal gut microbiota bacterial, including the observed species number, Chao1 index, and Shannon index. (D) Principal coordinate analysis (PCA) of gut microbiomes. (E) Principal component analysis (PCoA) of gut microbiomes. (F) The differences in intestinal bacterial structure at the genus level among the groups (G) The relative abundance of bacterial flora at the genus level. (H) The relative abundance of lactobacillus. (I) The relative abundance of Lachnospiraceae-NK4A136. The results are presented as mean ± SD. ^aP < 0.05 vs Control group, ^bP < 0.01 vs Control group, ^cP < 0.05 vs IR group, ^eP < 0.05 vs L-Met group.