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Ranking order of CLDN3 positive immunostaining in different human tumors.In ccRCC, low CLDN3 staining was strongly linked to poor ISUP (p < 0.0001), Fuhrman (p < 0.0001), and Thoenes (p < 0.0001) grades, advanced pT stage (p < 0.0001), high UICC stage (p = 0.0006), distant metastasis (p = 0.0011), as well as shortened overall (p = 0.0118; Fig. 4a) and recurrence-free (p < 0.0001; Fig. 4b) survival
