Table 2.
CLDN3 immunostaining and tumor phenotype
| CLDN3 immunostaining | |||||||
|---|---|---|---|---|---|---|---|
| n | negative (%) | weak (%) | moderate (%) | strong (%) | p | ||
| Invasive breast cancer of no special type | All cancers | 294 | 0.3 | 13.3 | 9.9 | 76.5 | |
| pT1 | 115 | 0.0 | 10.4 | 9.6 | 80.0 | 0.1192 | |
| pT2 | 147 | 0.7 | 11.6 | 11.6 | 76.2 | ||
| pT3-4 | 29 | 0.0 | 31.0 | 3.4 | 65.5 | ||
| G1 | 8 | 0.0 | 0.0 | 12.5 | 87.5 | 0.6289 | |
| G2 | 160 | 0.0 | 13.1 | 10.6 | 76.3 | ||
| G3 | 126 | 0.8 | 14.3 | 8.7 | 76.2 | ||
| pN0 | 148 | 0.7 | 12.8 | 9.5 | 77.0 | 0.6641 | |
| pN + | 117 | 0.0 | 12.8 | 12.0 | 75.2 | ||
| Endometrioid endometrial carcinoma | pT1 | 105 | 0.0 | 6.7 | 4.8 | 88.6 | 0.2436 |
| pT2 | 23 | 0.0 | 8.7 | 17.4 | 73.9 | ||
| pT3-4 | 37 | 0.0 | 8.1 | 13.5 | 78.4 | ||
| pN0 | 50 | 0.0 | 4.0 | 14.0 | 82.0 | 0.7811 | |
| pN + | 29 | 0.0 | 6.9 | 10.3 | 82.8 | ||
| Clear cell renal cell carcinoma | all cancers | 999 | 10.0 | 25.9 | 16.5 | 47.5 | |
| ISUP | |||||||
| 1 | 229 | 5.2 | 18.3 | 13.1 | 63.3 | < 0.0001 | |
| 2 | 355 | 5.9 | 25.4 | 16.9 | 51.8 | ||
| 3 | 221 | 10.4 | 34.4 | 17.6 | 37.6 | ||
| 4 | 64 | 48.4 | 23.4 | 14.1 | 14.1 | ||
| Fuhrman | |||||||
| 1 | 54 | 1.9 | 11.1 | 5.6 | 81.5 | < 0.0001 | |
| 2 | 598 | 5.7 | 24.4 | 17.4 | 52.5 | ||
| 3 | 252 | 11.9 | 32.1 | 18.7 | 37.3 | ||
| 4 | 78 | 43.6 | 28.2 | 11.5 | 16.7 | ||
| Thoenes | |||||||
| 1 | 300 | 6.0 | 19.7 | 15.3 | 59.0 | < 0.0001 | |
| 2 | 418 | 9.6 | 30.4 | 19.6 | 40.0 | ||
| 3 | 90 | 31.1 | 33.3 | 7.8 | 27.8 | ||
| UICC | |||||||
| 1 | 261 | 6.9 | 24.9 | 14.6 | 53.6 | 0.0006 | |
| 2 | 31 | 12.9 | 32.3 | 9.7 | 45.2 | ||
| 3 | 83 | 21.7 | 26.5 | 10.8 | 41.0 | ||
| 4 | 65 | 26.2 | 32.3 | 7.7 | 33.8 | ||
| pT1 | 574 | 5.1 | 23.7 | 17.1 | 54.2 | < 0.0001 | |
| pT2 | 111 | 6.3 | 22.5 | 20.7 | 50.5 | ||
| pT3-4 | 303 | 20.8 | 31.0 | 14.2 | 34.0 | ||
| pN0 | 151 | 15.2 | 27.2 | 11.9 | 45.7 | 0.1249 | |
| pN + | 22 | 27.3 | 27.3 | 22.7 | 22.7 | ||
| pM0 | 88 | 9.1 | 19.3 | 12.5 | 59.1 | 0.0011 | |
| pM + | 83 | 25.3 | 31.3 | 10.8 | 32.5 | ||
| Papillary renal cell carcinoma | All cancers | 239 | 2.9 | 5.9 | 9.2 | 82.0 | |
| ISUP | |||||||
| 1 | 29 | 0.0 | 3.4 | 13.8 | 82.8 | 0.0019 | |
| 2 | 113 | 0.9 | 4.4 | 3.5 | 91.2 | ||
| 3 | 62 | 6.5 | 8.1 | 17.7 | 67.7 | ||
| 4 | 4 | 25.0 | 25.0 | 25.0 | 25.0 | ||
| Fuhrman | |||||||
| 1 | 2 | 0.0 | 0.0 | 0.0 | 100 | 0.0064 | |
| 2 | 153 | 0.7 | 3.9 | 5.9 | 89.5 | ||
| 3 | 63 | 6.3 | 7.9 | 15.9 | 69.8 | ||
| 4 | 8 | 12.5 | 12.5 | 37.5 | 37.5 | ||
| Thoenes | |||||||
| 1 | 45 | 0.0 | 4.4 | 13.3 | 82.2 | 0.0315 | |
| 2 | 128 | 2.3 | 6.3 | 7.0 | 84.4 | ||
| 3 | 14 | 14.3 | 0.0 | 28.6 | 57.1 | ||
| UICC | |||||||
| 1 | 77 | 1.3 | 3.9 | 9.1 | 85.7 | 0.0625 | |
| 2 | 9 | 0.0 | 22.2 | 22.2 | 55.6 | ||
| 3 | 3 | 0.0 | 0.0 | 0.0 | 100.0 | ||
| 4 | 9 | 22.2 | 22.2 | 11.1 | 44.4 | ||
| pT1 | 169 | 1.8 | 5.3 | 5.3 | 87.6 | 0.0273 | |
| pT2 | 39 | 2.6 | 7.7 | 17.9 | 71.8 | ||
| pT3-4 | 25 | 12.0 | 8.0 | 16.0 | 64.0 | ||
| pN0 | 20 | 0.0 | 10.0 | 15.0 | 75.0 | 0.2338 | |
| pN + | 12 | 16.7 | 8.3 | 16.7 | 58.3 | ||
| pM0 | 23 | 0.0 | 4.3 | 17.4 | 78.3 | 0.0357 | |
| pM + | 11 | 18.2 | 18.2 | 27.3 | 36.4 | ||
| Ductal adenocarcinoma of the pancreas | pT1 | 8 | 50 | 25 | 0 | 25 | 0.662 |
| pT2 | 43 | 37.2 | 39.5 | 9.3 | 14 | ||
| pT3 | 242 | 35.5 | 33.9 | 12.8 | 17.8 | ||
| pT4 | 17 | 52.9 | 29.4 | 11.8 | 5.9 | ||
| G1 | 10 | 50 | 20 | 0 | 30 | 0.092 | |
| G2 | 218 | 35.3 | 33 | 11.9 | 19.7 | ||
| G3 | 68 | 41.2 | 38.2 | 13.2 | 7.4 | ||
| pN0 | 65 | 40 | 29.2 | 12.3 | 18.5 | 0.8041 | |
| pN + | 244 | 36.1 | 35.7 | 11.9 | 16.4 | ||
| Gastric adenocarcinoma | All cancers | 316 | 13.9 | 13.9 | 9.8 | 62.7 | |
| pT1-2 | 42 | 7.1 | 7.1 | 4.8 | 81.0 | 0.2596 | |
| pT3 | 103 | 15.5 | 11.7 | 12.6 | 60.2 | ||
| pT4 | 105 | 15.2 | 14.3 | 10.5 | 60.0 | ||
| pN0 | 61 | 13.1 | 8.2 | 8.2 | 70.5 | 0.5204 | |
| pN + | 189 | 13.8 | 13.8 | 11.1 | 61.4 | ||
| Urothelial carcinoma | All cancers | 619 | 50.7 | 27.6 | 10.3 | 11.3 | |
| pTa G2 low | 79 | 77.2 | 16.5 | 5.1 | 1.3 | < 0.0001 | |
| pTa G2 high | 73 | 63.0 | 26.0 | 8.2 | 2.7 | ||
| pTa G3 | 86 | 36.0 | 37.2 | 9.3 | 17.4 | ||
| pT2 | 97 | 50.5 | 20.6 | 14.4 | 14.4 | 0.5546 | |
| pT3 | 183 | 46.4 | 31.1 | 10.4 | 12.0 | ||
| pT4 | 92 | 43.5 | 28.3 | 12.0 | 16.3 | ||
| G2 | 18 | 55.6 | 27.8 | 11.1 | 5.6 | 0.6878 | |
| G3 | 354 | 46.3 | 27.7 | 11.9 | 14.1 | ||
| pN0 | 203 | 51.2 | 27.1 | 12.3 | 9.4 | 0.0111 | |
| pN + | 143 | 38.5 | 29.4 | 11.2 | 21.0 | ||
| L0 | 146 | 52.7 | 27.4 | 11.0 | 8.9 | 0.0062 | |
| L1 | 132 | 36.4 | 30.3 | 11.4 | 22.0 | ||
Abbreviations: G grade, pM pathologic status of distant metastasis, pN pathologic lymph node status, pT pathologic tumor stage, L Lymphatic invasion status, ISUP International Society of Urologic Pathologists, UICC Union for International Cancer Control