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. 2024 Dec 11;34(1):e5253. doi: 10.1002/pro.5253

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© 2024 The Author(s). Protein Science published by Wiley Periodicals LLC on behalf of The Protein Society.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Proteomic and metabolic changes due to S. pneumoniae GAPN knockout. (a) Volcano plot indicating proteins that increase (blue, left) and decrease (red, right) upon GAPN knockout of cells grown in culture. (b) Volcano plot indicating proteins that increase (blue, left) and decrease (red, right) upon GAPN knockout for cells derived from infected mice. (c) Volcano plot indicating metabolites that increase (blue, left) and decrease (red, right) upon GAPN knockout of cells grown in culture. (d) Volcano plot indicating metabolites that increase (blue, left) and decrease (red, right) upon GAPN knockout derived from the BAL fluid of infected mice. Intensities were derived and compared in triplicate between WT and GAPN knockout strains.