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. 2024 Oct 30;15(12):e02493-24. doi: 10.1128/mbio.02493-24

Fig 3.

Three plots tracking nucleotide frequency changes in SARS-CoV-2 over time: decreasing C frequency, increasing U frequency, and base frequency changes for U, A, G, and C, highlighting evolutionary trends across various variants from 2020-2024.

Changes in SARS-CoV-2 genome composition since the start of the pandemic. (A and B) Frequencies of C and U bases in individual genome sequences of SARS-CoV-2 isolates collected at different time points from the start of the pandemic. Lineage assignments are indicated. Circles indicate the mean sampling date and composition of consensus sequences from the 10 lineages and the prototype sequence; diamonds indicate mean compositions of individual sequences. (C) Differences in A, C, G, and U base frequencies between the genome sequence of the PT (Wuhan-1) and of lineage consensus sequences collected at different time points from the start of the pandemic.