TABLE 1.
Demographics summary by cohort.
| Tissue | Cohort | Sample Size | Mean Age (SD) | %Male | %APOE ε4+ | %AD Cases |
|---|---|---|---|---|---|---|
| Plasma | ||||||
| Knight‐ADRC | 2317 | 75.2 (10.0) | 45.8 | 39.9 | 38.1 | |
| CSF | ||||||
| ADNI | 689 | 73.7 (7.5) | 58.2 | 50.2 | 75.6 | |
| PPMI | 785 | 61.8 (9.4) | 55.1 | N/A | 0.0 | |
| FACE | 438 | 71.9 (8.3) | 41.1 | 35.6 | 54.3 | |
| DIAN | 193 | 38.6 (10.7) | 48.4 | 27.6 | 61.7 | |
| Knight‐ADRC | 805 | 71.4 (8.7) | 46.7 | 39.0 | 22.1 | |
| Barcelona‐1 | 197 | 68.8 (7.5) | 52.3 | N/A | 32.0 | |
| Total | 3107 |
Note: This table summarizes demographic information of the participants included in the plasma and CSF association analyses. The %APOE ε4+ column specifies the percentage of each cohort that included individuals with at least one APOE ε4 allele. There is some overlap between the plasma and CSF Knight‐ADRC sample. All participants were European in ancestry based on principal component analysis.
Abbreviations: AD, Alzheimer's disease; ADNI, Alzheimer's Disease Neuroimaging Initiative; ADRC, Alzheimer's Disease Research Center; CSF, cerebrospinal fluid; DIAN, Dominantly Inherited Alzheimer Network; FACE, Fundació Alzheimer's Center; PPMI, Parkinson's Progression Markers Initiative; SD, standard deviation.