. 2018 Jul 12;6(4):10.1128/microbiolspec.arba-0030-2018. doi: 10.1128/microbiolspec.arba-0030-2018

TABLE 3.

MIC values (range in μg/ml) for various antimicrobials against avian Mycoplasma species (M. gallisepticum and M. synoviae)

Antimicrobials^b	M. gallisepticum		M. synoviae
Antimicrobials^b	Old strains^a	Recent strains^a	Old strains^a	Recent strains^a
Tetracyclines:
Tetracycline	0.08–0.64	ND	1–2	ND
Oxytetracycline	0.05–0.5	≤0.03–4	0.1–>100	0.39–3.12
Doxycycline	ND^d	≤0.03–0.79	ND	ND
Chlortetracycline	ND	0.2–32	1–2	0.32–>12.5
Macrolides:
Erythromycin	0.02–>80	≤0.03–>64	>40	32–>128
Tylosin	0.0025–10	≤0.03–5	0.025–10	≤0.006–2
Tilmicosin	ND	≤0.03–32	ND	0.03–>8
Josamycin	ND	0.2–>50	ND	ND
Spiramycin	0.5–>20	ND	ND	ND
Tylvalosin	ND	ND	ND	≤0.006–0.012
Lincosamides:
Lincomycin	1.25–40	0.1–12.5	1–2	0.125–8
Pleuromutilins:
Tiamulin	0.0005–1	≤0.03–2	0.1–1	0.012–0.12
Fluoroquinolones:
Flumequine	2.5–10	ND	5–50	ND
Enrofloxacin	0.005–1^c	≤0.03–10	0.1–10^c	0.03–8
Danofloxacin	0.01–0.5	ND	0.1–0.5	ND
Amphenicols:
Florfenicol	ND	0.125–4	ND	ND
Aminoglycosides:
Spectinomycin	0.5–10	≤0.03–2	0.5–2	ND
Gentamicin	≥10–≥50	1–32	1	ND

^{^a}

Data were compiled from studies performed on old strains (before 2000) (26, 41, 47, 62, 72–75) and more recent strains (2000 to 2016) (29, 32, 33, 76–82). Several methods were used to determine these MIC values.

^{^b}

Antimicrobial family and antibiotics belonging to this family.

^{^c}

For enrofloxacin, one study (29) compared isolates from 1997 to 2003 and from 2005 to 2006; results obtained for isolates from 1997 to 2003 are classified as old strains in this table.

^{^d}

ND, no data found.