TABLE 5.

MIC values (range in μg/ml) for various antimicrobials against ruminant Mycoplasma species (M. bovis and M. agalactiae)

Antimicrobialsb	M. bovis		M. agalactiae
	Old strainsa	Recent strainsa	Old strainsa	Recent strainsa
Tetracyclines:
Tetracycline	0.05–1	0.05–>256	ND	0.125–32
Oxytetracycline	0.1–128	0.05–>256	0.1–4	0.06–16
Doxycycline	NDc	0.023–8	ND	0.008–1
Chlortetracycline	3.12–100	0.25–>32	ND	0.125–8
Macrolides:
Erythromycin	50–>100	1–>512	ND	6–>256
Tylosin	0.025–>100	0.125–>256	0.1–1	0.03–12.8
Tilmicosin	1–>128	0.5–>1024	0.12–1	0.12–64
Spiramycin	0.39–>100	ND	ND	0.125–4
Gamithromycin	32–>128	128–>128	ND	4–32
Tulathromycin	1–64	0.25–>1024	ND	1–8
Azythromycin	ND	0.25–>256	ND	ND
Lincosamides:
Lincomycin	0.39–3.12	0.06–>256	ND	0.125–4
Clindamycin	ND	≤0.03–>256	ND	≤0.12
Pleuromutilins:
Tiamulin	0.05–1	ND	0.05–0.25	0.125–0.5
Valnemulin	ND	≤0.03	ND	ND
Fluoroquinolones:
Flumequine	10–100	ND	ND	>128
Enrofloxacin	0.05–1	≤0.03–32	0.05–1	0.06–1.6
Danofloxacin	0.125–2.5	0.08–32	0.05–2.5	0.25–0.5
Marbofloxacin	0.25–1	0.25–>32	ND	0.1–12.8
Amphenicols:
Chloramphenicol	6.25–25	0.25–32	ND	1–8
Florfenicol	1–64	0.06–32	1–8	2–8
Aminoglycosides:
Spectinomycin	1–>128	0.38–>256	1–8	0.25–8
Gentamicin	ND	2.8	ND	0.5–16

^a Data were compiled from studies performed on old strains (before 2000) (36, 38, 41, 49, 75, 87, 101) and more recent strains (2000 to 2016) (34, 36, 38, 58, 64, 65, 98–100, 102–105, 107–114). Several methods were used to determine these MIC values.

^b Antimicrobial family and antibiotics belonging to this family.

^c ND, No data found.