TABLE 1.
Insertion sequences and composite transposonsa
| ISb | Tnc | Associated resistance(s)/phenotype(s) | Determinant(s) | TDd (bp) |
|---|---|---|---|---|
| IS256 | Tn4001e | Gentamicin/kanamycin/tobramycin | aacA-aphD | 8 |
| Phenicols/lincosamides/oxazolidinones/pleuromutilins/streptogramin A | cfr | |||
| IS257f | Kanamycin/neomycin/paromomycin/tobramycin | aadD | 8 | |
| Kanamycin/neomycin | aphA-3 | |||
| Bacitracin | bcrAB | |||
| Bleomycin | ble | |||
| Cadmium | cadDX | |||
| Trimethoprim | dfrK | |||
| MLS | ermC | |||
| Fosfomycin | fosB5 | |||
| Fusidic acid | fusB | |||
| Mupirocin | ileS2 (mupA) | |||
| Lysostaphin immunity factor | lif | |||
| Preprolysostaphin | lss | |||
| Antiseptics/disinfectants | qacC | |||
| Streptothricin | sat4 | |||
| Tetracycline | tetK | |||
| Tetracycline | tetL | |||
| Streptogramin A | vat(A) | |||
| Streptogramin A/pleuromutilins/lincosamides | vga(A) | |||
| Streptogramin B | vgb(A) | |||
| Tn4003 | Trimethoprim | dfrA | ||
| Tn4004 | Mercury | merAB | ||
| Tn6072 | Gentamicin/kanamycin/tobramycin | aacA-aphD | ||
| Tn6072 | Spectinomycin | spc | ||
| IS1181 | 8 | |||
| IS1182 | Tn5405g | Streptomycin | aadE | 8 |
| Tn5405 | Kanamycin/neomycin | aphA-3 | ||
| Tn5405 | Streptothricin | sat4 | ||
| IS1272 | TnSha1 | Triclosan | fabI | Absent |
| TnSha2 | Triclosan | fabI | ||
| IS1293 | Lysostaphin immunity factor | lif | Unknown | |
| Preprolysostaphin | lss | |||
| IS21-558f | Phenicols/lincosamides/oxazolidinones/pleuromutilins/streptogramin A | cfr | 6 | |
| Lincosamides | lsa(B) | |||
| ISEnfa4 | Phenicols/lincosamides/oxazolidinones/pleuromutilins/streptogramin A | cfr | 8 | |
| ISSau10 | Kanamycin/neomycin/paromomycin/tobramycin | aadD | 8 | |
| Trimethoprim | dfrK | |||
| MLS | ermC | |||
| MLS | ermT | |||
| Tetracycline | tetL | |||
| ISSha1 | 8 |
See Paulsen et al. (25), Firth and Skurray (26), Fu et al. (237), Allignet and El Solh (238), Chen et al. (239), Kadlec and Schwarz (240), Highlander et al. (232), O’Neill and Chopra (241), de Vries et al. (242), and the text for references. Additional elements detected in genome sequences but not described here (e.g., ISSau1 through ISSau8 and ISSau11) are listed in ISfinder (http://www-is.biotoul.fr).
In the case of IS, association is based on probable involvement in the acquisition and dissemination of the resistance.
Associated composite transposons are shown.
TD, target duplication.
Tn3851 and Tn4031 are likely to be similar or identical to Tn4001.
IS257 is also known as IS431, and IS21-558 is also known as ISSau9.
Tn3854 may be similar to Tn5405.