TABLE 5.

Distribution of pco/sil and yersiniabactin biosynthesis genes among Enterobacteriaceae

Genusa	Number of sequences analyzedb	Occurrence of copper/silver tolerance determinants
		pco c	sil d	pco/sil e	Yersiniabactin synthesisf	pco/silP and yersiniabactin synthesisg
Citrobacter	60 genomes	10	10	10	3	0
	50 plasmids	0	0	0	0
Cronobacter	29 genomes	1	1	1	0	0
	22 plasmids	6	6	6	0
Enterobacter	167 genomes	22	28	21	0	0
	121 plasmids	6	7	6	0
Escherichia	946 genomes	33	31	30	121	18
	901 plasmids	7	11	7	0
Klebsiella	674 genomes	2	3	2	82	30
	628 plasmids	92	92	91	2
Kluyvera	6 genomes	0	0	0	0	0
	4 plasmids	1	1	1	0
Kosakonia	10 genomes	1	1	1	0	0
	4 plasmids	0	0	0	0
Pantoea	66 genomes	0	0	0	0	0
	61 plasmids	0	1	0	0
Raoultella	9 genomes	1	1	1	4	1
	8 plasmids	0	0	0	0
Salmonella	602 genomes	14	13	13	5	0
	369 plasmids	4	6	4	7
Serratia	64 genomes	0	0	0	0	0
	27 plasmids	2	2	2	0
Yersinia	192 genomes	0	0	0	33	0
	153 plasmids	0	0	0	0

^a Genera of Enterobacteriaceae harboring pco, sil, and/or ybt.

^b Number of completed genomic and plasmid sequences of respective genera available for Microbial Genome BLAST (http://blast.ncbi.nlm.nih.gov; accessed 13 September 2017).

^c Analysis (blastn) using pco from pRJ1004 (GenBank accession number X83541.1 [146]) as query.

^d Analysis (blastn) using sil from pMG101 (GenBank accession number NG_035131.1 -[153]) as query.

^e Analysis (blastn) using pco (GenBank accession number X83541.1; [146]) and sil (accession number KC146966.1 [151]) from pRJ1004 as query.

^f Analysis (tblastn) using Ybt peptide/polyketide synthetase HMWP1 (GenBank accession number AAC69588.1 [246]) as query.

^g Number of strains harboring pco/sil and ybt with determinant being located on chromosome and/or plasmid, respectively.