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. Author manuscript; available in PMC: 2024 Dec 11.
Published in final edited form as: Nature. 2024 Aug 7;633(8028):207–215. doi: 10.1038/s41586-024-07767-5

Extended Data Figure 4: Sensory neurons drive metastatic colonization in multiple breast cancer models.

Extended Data Figure 4:

(a-c) Tail vein injections of mCh+ 67NR cancer cells with or without DRG neurons. (a) Schematic. (b) CGRP+/ βIII-tubulin+ neuronal cell bodies in mice co-injected with DRG neurons. r = 3 lungs/ group. (c) mCh+ metastases. ****p < 0.0001, Mann-Whitney test. Mean ± SD.

(d-f) Co-transplantation of EO771 cancer cells and DRG neurons. (d) Schematic. (e) Tumour growth. *p = 0.0345, t-test. Mean ± SEM. (f) Number of micro-metastases counted by H&E. *p = 0.0249, t-test. Mean ± SD.