Table.

The concentrations of anti-PEG IgG and IgM in each mouse in the pre-existing anti-PEG antibody mouse model

Naïve group (n = 10)
Ear punching identification no.	13-UN	13-L1	13-R1	13-L2	13-LR	14-UN	14-L1	14-R1	14-L2	14-LR	Average concentration (μg/ml)
Anti-PEG IgG concentration (μg/ml)	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00
Anti-PEG IgM concentration (μg/ml)	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00
Anti-PEG IgG + IgM concentration (μg/ml)	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00
Group 1 (n = 10)
Ear punching identification no.	2-L1	8-UN	7-R1	12-R1	5-UN	4-L1	3-R1	11-UN	5-R1	9-R1	Average concentration (μg/ml)
Anti-PEG IgG concentration (μg/ml)	1.13	3.04	7.02	0.46	0.78	13.14	21.47	12.03	18.88	27.22	10.52
Anti-PEG IgM concentration (μg/ml)	0.17	0.23	0.27	0.30	0.39	0.64	0.18	0.15	0.40	0.19	0.29
Anti-PEG IgG + IgM concentration (μg/ml)	2.30	3.27	7.29	0.76	1.17	13.78	21.65	12.18	19.28	27.41	10.81
Group 2 (n = 10)
Ear punching identification no.	4-UN	10-R1	10-L1	10-UN	11-L1	9-UN	12-L1	6-L1	11-R1	2-R1	Average concentration (μg/ml)
Anti-PEG IgG concentration (μg/ml)	45.77	41.46	32.64	31.51	54.60	31.28	26.16	46.75	27.13	29.67	36.70
Anti-PEG IgM concentration (μg/ml)	0.19	0.10	0.12	0.21	0.31	0.30	8.36	52.77	9.74	3.18	7.53
Anti-PEG IgG + IgM concentration (μg/ml)	45.96	41.56	32.76	31.72	54.91	31.58	34.52	99.52	36.87	32.85	44.23