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Schematic representation of the delivery of therapeutic agents by MSC to tumor site via various mechanisms: 1. Simple diffusion, 2. Endocytosis, 3. Transporters such as hCNT1, hENT1. Small-molecule anticancer agents are enclosed in vesicles produced by MSCs. The existence of EVs between MSCs and cancer cells implies that a vesicular system can transport the small-molecule anticancer agent to the cancer cells. (Adapted from Szewc et al.14 and Jia et al.15).
