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. Author manuscript; available in PMC: 2024 Dec 11.
Published in final edited form as: Nat Rev Genet. 2022 Oct 31;24(4):211–234. doi: 10.1038/s41576-022-00539-9

Fig. 2 |. Dynamic non-B DNA structure induced by transcription.

Fig. 2 |

The inverted-repeat sequence (blue) is maintained in B-DNA form on histones and is unwrapped during transcription. The progressing transcription machinery unwinds DNA from the nucleosome structure and creates positive supercoiling in front (removed by topoisomerases) and negative supercoiling behind, which facilitates non-B DNA structure formation (shown in the schematic as a cruciform). RNAP, RNA polymerase; ssDNA, single-stranded DNA.