Figure 2.

Exercise profiling of Ercc1 ^Δ/− mice and organ weights following sActRIIB, dietary restriction and combined at 16 weeks of age. (A) Average time spent on an accelerating rotarod of wild‐type and Ercc1 ^Δ/− mice on different interventions at 16 weeks of age. (B) Motor coordination on the balance beam indicated by time to cross the beam and the number of missteps made during. (C) Grip strength measure of forelimbs and all limbs normalized to body weight. (D) Dissected muscle weights for tibialis anterior (TA), extensor digitorum longus (EDL), gastrocnemius (Gas.), soleus (Sol.), and plantaris (Plant.) normalized to tibia length. (E) Body weight and (F) indicated organ weights at week 16. n = 4 animals per group. Mean ± SE and individual data points are indicated. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.