FIG. 4.

Splenic T-cell proliferative responses to viral and myelin epitopes in costimulatory antagonist-treated mice. Splenocytes from three representative animals were taken at 20 (A) and 63 days (B) postinfection. Splenocytes (10⁶/well) were challenged with 5 μg of UV-inactivated TMEV or 200 μM concentrations of the indicated peptides for 72 h and pulsed with [³H]TdR for an additional 18 to 20 h. All groups made equivalent responses to concanavalin A (1 ng/ml) stimulation. Results are expressed as changes in counts per minute (backgrounds subtracted).