FIG. 6.

TMEV-specific antibody responses are abolished in virus-infected mice treated with CTLA-4 Ig or anti-B7-1 plus anti-B7-2 MAbs. Serum was collected 13 days postinfection from three representative mice per group and pooled for analysis. Anti-TMEV antibody levels were determined on triplicate samples as detailed in Materials and Methods. Results are expressed as the net absorbance at 450 nm (OD for representative blank wells subtracted). Values are representative of three or four separate experiments.