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Viral titers in the CNS of costimulatory antagonist-treated mice are significantly enhanced in CTLA-4 Ig-treated mice. Spinal cords from three representative animals per treatment group were isolated 21 days postinfection, pooled, and homogenized in PBS. Viral plaque assays were carried out as outlined in Materials and Methods to determine the amount of live virus persisting in TMEV-infected mice. Results are representative of three or four separate experiments.
