Figure 4.

Infusion of AgRP ameliorates INC bone disorder in Ctns ^−/− mice. Ctns ^−/−  + vehicle mice were fed ad libitum WT + vehicle, WT + AgRP, and Ctns ^−/−  + AgRP mice were pair‐fed to that of Ctns ^−/−  + vehicle mice. Whole‐body BMC, BMD, and bone area were measured. Femoral BMC, BMD, area, and length were also shown data are expressed as mean ± SEM. Results of Ctns ^−/−  + vehicle mice were compared with that of WT + vehicle mice whereas results of Ctns ^−/−  + AgRP mice were compared with that of WT + AgRP mice. Results of Ctns ^−/−  + vehicle mice were also compared with Ctns ^−/−  + AgRP mice. Ns, not significant, *P < 0.05, **P < 0.01.