. 2024 Aug 29;15(6):2447–2459. doi: 10.1002/jcsm.13579

Table 1.

Serum and blood chemistry of mice during the 12‐month study

	WT	Ctns ^−/−	WT	Ctns ^−/−	WT	Ctns ^−/−	WT	Ctns ^−/−
	1‐month‐old (n = 8)	1‐month‐old (n = 8)	4‐month‐old (n = 8)	4‐month‐old (n = 8)	9‐month‐old (n = 8)	9‐month‐old (n = 8)	12‐month‐old (n = 8)	12‐month‐old (n = 8)
BUN (mg/dL)	24.8 ± 2.1	25.8 ± 1.5	26.9 ± 1.3	25.8 ± 0.6	27.0 ± 1.5	59.2 ± 2.1 ^a	28.3 ± 1.9	67.8 ± 7.8 ^a
Creatinine (mg/dL)	0.06 ± 0.02	0.05 ± 0.02	0.07 ± 0.01	0.07 ± 0.01	0.07 ± 0.01	0.11 ± 0.02 ^a	0.09 ± 0.01	0.18 ± 0.02 ^a
Bicarbonate (mg/dL)	25.8 ± 2.3	26.8 ± 1.6	27.5 ± 0.5	27.3 ± 1.2	27.2 ± 0.5	27.1 ± 0.4	28.8 ± 1.4	26.9 ± 0.7
Calcium (mg/dL)	9.53 ± 0.12	9.27 ± 0.26	9.62 ± 0.10	10.02 ± 0.09	9.32 ± 0.11	9.21 ± 0.05	9.43 ± 0.12	9.49 ± 0.05
Phosphorus (mg/dL)	9.54 ± 0.21	9.27 ± 0.16	9.60 ± 0.32	8.20 ± 0.26 ^b	8.65 ± 0.16	7.76 ± 0.22 ^b	8.82 ± 0.31	7.38 ± 0.16 ^b
Intact PTH (pg/mL)	90.4 ± 6.3	90.5 ± 4.8	93.8 ± 5.1	101.1 ± 2.7	103.2 ± 10.4	264.6 ± 9.5 ^a	118.9 ± 11.7	432.8 ± 12.8 ^a
25(OH)D₃ (ng/mL)	123.2 ± 19.3	101.8 ± 12.9	113.2 ± 15.7	108.2 ± 14.8	120.1 ± 20.5	46.9 ± 8.1 ^b	106.5 ± 12.1	50.7 ± 12.6 ^b
1,25(OH)₂D₃ (pg/mL)	302.4 ± 16.4	252.6 ± 32.7	254.5 ± 17.4	184.4 ± 14.8	276.4 ± 30.6	157.8 ± 19.4 ^b	276.8 ± 17.9	115.7 ± 32.6 ^b
FGF23 (pg/mL)	102.6 ± 18.3	105.8 ± 21.7	105.2 ± 11.4	113.2 ± 18.4	121.5 ± 20.6	202.1 ± 19.6 ^a	108.2 ± 15.2	216.9 ± 22.9 ^a
Leptin (ng/dL)	2.21 ± 0.16	2.37 ± 0.12	2.33 ± 0.09	2.34 ± 0.11	2.32 ± 0.05	3.49 ± 0.06 ^a	2.49 ± 0.8	5.54 ± 0.12 ^a

All mice were fed ad libitum. Data are expressed as mean ± SEM. Results of Ctns ^−/− mice were compared with age‐matched WT mice.

BUN, blood urinary nitrogen; FGF23, fibroblast growth factor 23; PTH, parathyroid hormone.

^{^a}

P < 0.05, significantly higher in Ctns ^−/− mice than WT mice.

^{^b}

P < 0.05, significantly lower in Ctns ^−/− mice than WT mice.