TABLE 3.
Association between SLCO1B1 haplotype and severity of DILI and MTX clearance.
| Characteristics | Non/mild DILI (N = 606) | Moderate/severe DILI (N = 142) | p a | No delay in clearance (N = 574) | Delay in clearance (N = 174) | p a |
| Haplotype | 0.163 | 0.701 | ||||
| *1a | 119 (20%) | 38 (27%) | 132 (21.2%) | 25 (21.6%) | ||
| *1b | 416 (70%) | 93 (65%) | 432 (69.2%) | 77 (66.4%) | ||
| *5 | 0 | 0 | 0 | 0 | ||
| *15 | 63 (11%) | 11 (7.7%) | 60 (9.6%) | 14 (12.1%) | ||
| Haplotype groups | 0.247 | 0.459 | ||||
| *1a/*1b, *1a/*1a, *1b/*1b | 239 (80%) | 61 (86%) | 255 (81.7%) | 45 (77.6%) | ||
| --/*15 | 60 (20%) | 10 (14%) | 57 (18.3%) | 13 (22.4%) |
The value was presented as N (%), a, analyzed by either Chi-square test or Fisher’s exact test. --/*15 means at least one *15 (*1a/*15, *1b/*15, *5/*15).