TABLE 4.

Binary logistic regression analysis of moderate and severe DILI predictors.

Predictor	Estimate	95% CI lower	95% CI upper	SE	Z	p	OR
Intercept	−2.12459	−3.83732	−0.41186	0.87386	−2.431	0.015	0.119
Sex
Female vs. Male	0.78127	0.14191	1.42062	0.32621	2.395	0.017	2.184
MTX dose (g)	0.18660	0.12879	0.24441	0.02950	6.326	<0.001	1.205
C24hMTX (μmol/L)	0.00369	−0.00580	0.01318	0.00484	0.762	0.446	1.004
Cr (μmol/L)	−0.01461	−0.03346	0.00423	0.00961	−1.520	0.128	0.985
ABCB1.rs1128503
GG + GA vs. AA	0.75206	0.10507	1.39905	0.33010	2.278	0.023	2.121
SLCO1B1 haplotypes
*1b/*1b vs. *1a/*1a	−1.67769	−3.26529	−0.09009	0.81002	−2.071	0.038	0.187
*1a/*1b vs. *1a/*1a	−0.76200	−2.26238	0.73839	0.76552	−0.995	0.320	0.467
*1b/*15 vs. *1a/*1a	−2.24372	−4.09526	−0.39218	0.94468	−2.375	0.018	0.106
*1a/*15 vs. *1a/*1a	−1.62841	−3.64182	0.38501	1.02727	−1.585	0.113	0.196
*15/*15 vs. *1a/*1a	−1.33123	−4.27360	1.61114	1.50124	−0.887	0.375	0.264

^a Estimates represent the log odds of “moderate/severe DILI” vs. “non/mild DILI”. OR, for MTX, dose, C_24hMTX, and Cr means risk effect size of 1-unit increased in the values of each of these variables.