Extended Data Fig. 4. Top biological processes, molecular functions, and cellular components enriched among proteins associated with coronary artery disease, heart failure, atrial fibrillation, and aortic stenosis.
Top biological functions, molecular pathways, and cellular components were queried using the Gene Ontology resource22,23 via Enrichr24. Enrichment tests were performed against a background gene set that included the genes corresponding to all 1,459 proteins tested in primary analyses. Gene sets with a false discovery rate-adjusted two-sided P < 0.05 were considered statistically significant. Bright colors indicate statistical significance, whereas dull colors indicate no statistical significance. All P-values shown were unadjusted for multiple comparisons.