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. 2024 Nov 20;636(8042):404–411. doi: 10.1038/s41586-024-08217-y

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 4 — We meta-analyzed the GWASs derived from DDD-UKHLS (6,397 cases with neurodevelopmental conditions and 9,270 controls from UKHLS) and GEL (3,618 cases and 13,667 controls). We used overlapping SNPs with MAF > 1% in both cohorts. (A) Manhattan plot. The red line indicates the genome-wide significance threshold (5×10⁻⁸). (B) Quantile-quantile plot. GWAS summary statistics including exact P values are available in Supplementary Data 3.