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. 2024 Jul 15;17(6):1389–1399. doi: 10.1007/s12265-024-10542-6

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — ABR-238901 protects against endothelial cell apoptosis induced by S100A8/A9 in-vitro. Induction of apoptosis was assessed by measurement of caspase-3/7 activity in cultured HUVECs stimulated for 24 h with 5 μg/ml or 10 μg/ml recombinant human S100A8/A9, with or without 100 μM ABR-238901. Caspase-3/7 enzymatic activity was measured in cell homogenates by a chemiluminescent assay. The results are expressed as fold change compared to vehicle-treated control cells. Data are presented as mean ± SD. *p < 0.05, **p < 0.01, ns not significant. ABR, ABR-238901