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. 2024 Dec 11;45:4. doi: 10.1007/s10571-024-01521-1

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Effect of various pharmacological interventions on histopathological alterations in hippocampal region. Vehicle control group showed normal neurons and pathological features. STZ group exhibited a significant presence of neutrophilic infiltration. Treatment with donepezil and rufinamide (50 and 100 mg/kg) demonstrated reduced neuronal degeneration and decresed neutrophilic infiltration in the hippocampal region. STZ and CREB inhibitor (666-15) group showed presence of neutrophilic infiltration. CREB inhibitor along with rufinamide and STZ revealed neutrophilic infiltration