Table 2.
Comparison of organ uptake values and tumor-to-organ ratios of [68Ga]Ga-9 compared to well-established PSMA radiotracers in LNCaP xenograft bearing mice. Data given as % injected activity per gram (% IA g−1) at 1 h p.i
Organ | [68Ga]Ga-PSMA-617a) | [177Lu]Lu-PSMA-617a) | [68Ga]Ga-PSMA-11a) | [68Ga]Ga-PSMA-11b) | [68Ga]Ga-9 |
---|---|---|---|---|---|
Tumor | 8.47 ± 4.09 | 11.20 ± 4.17 | 10.58 ± 4.5 | 7.70 ± 1.45 | 16.03 ± 1.32 |
Liver | 1.17 ± 0.10 | 0.22 ± 0.08 | – | 0.87 ± 0.05 | 3.10 ± 0.10 |
Kidney | 113.3 ± 24.4 | 137.2 ± 77.8 | 187.4 ± 25.3 | 139.4 ± 21.4 | 67.86 ± 8.35 |
Tumor-to-liver ratio | 7.24 | 50.91 | – | 8.85 | 5.17 |
Tumor-to-kidney ratio | 0.07 | 0.08 | 0.06 | 0.06 | 0.24 |