TABLE 2.

Comparison of fraction of Ki-67⁺ cells and absolute cell counts before and after acute SIV infection^a

% or no. of cells	Mean % or no. of cells ± SD
	Day 0 (n = 11)	Peakb (n = 11)	Wk 12 (n = 10)	Wk 24 (n = 10)
% of lymphocytes that are Ki-67+	6.9 ± 1.8	32.4 ± 17.0c	15.6 ± 5.6c	11.0 ± 6.1
No. of Ki-67+ lymphocytes/μl	302 ± 189	1,729 ± 1,377c	751 ± 538	441 ± 373
No. of lymphocytes/μl	4,189 ± 2,057	5,136 ± 2,228	4,667 ± 2,745	3,827 ± 1,335
% of CD3+ lymphocytes that are Ki-67+	5.2 ± 1.0	27.6 ± 9.9c	11.5 ± 4.3c	8.8 ± 4.8d
No. of Ki-67+ CD3+ cells/μl	144 ± 64	984 ± 556c	360 ± 300	204 ± 205
No. of CD3+ cells/μl	2,864 ± 1,309	3,464 ± 1,266	2,934 ± 1,524	2,288 ± 1,177
% of CD3+ CD8+ lymphocytes that are Ki-67+	4.9 ± 2.0	42.5 ± 11.1c	14.9 ± 4.9c	10.3 ± 6.3d
No. of Ki-67+ CD3+ CD8+ cells/μl	57 ± 37	862 ± 502c	289 ± 252d	147 ± 177
No. of CD3+ CD8+ cells/μl	1,233 ± 690	1,970 ± 905	1,759 ± 1,020	1,359 ± 871
% of CD3+ CD4+ lymphocytes that are Ki-67+	5.3 ± 0.8	7.1 ± 6.5	7.3 ± 4.0	6.1 ± 4.6
No. of Ki-67+ CD3+ CD4+ cells/μl	88 ± 37	117 ± 123	76 ± 55	47 ± 32d
No. of CD3+ CD4+ cells/μl	1,678 ± 654	1,529 ± 456	1,164 ± 610	904 ± 456d
% of NK cells that are Ki-67+	17.1 ± 9.8	49.6 ± 22.8c	14.6 ± 5.3	10.1 ± 5.6
No. of Ki-67+ NK cells/μl	102 ± 94	495 ± 864c	129 ± 107	42 ± 28d
No. of NK cells/μl	640 ± 506	836 ± 1,061	823 ± 725	520 ± 392
% of CD20+ lymphocytes that are Ki-67+	4.9 ± 1.3	3.8 ± 4.7	6.1 ± 3.4	2.6 ± 1.6
No. of Ki-67+ CD20+ cells/μl	48 ± 32	41 ± 75	79 ± 77	32 ± 23
No. of CD20+ cells/μl	820 ± 500	855 ± 495	1,145 ± 988	1,199 ± 609

^aGroup D animals were excluded from this analysis. 

^bPeak, time point after SIV infection at which the peak increase in Ki-67 expression was seen, i.e., week 1 for group A, week 2 for group B, and week 4 for group C animals. 

^cP < 0.01 (Wilcoxon signed-rank test) versus day 0 value. 

^dP < 0.05 (Wilcoxon signed-rank test) versus day 0 value.