TABLE 3.
Longitudinal phenotypic analysis of T lymphocytes in acute SIV infectiona
| Phenotype | % of CD4+ or CD8+ cells expressing phenotype at wk post-SIV infection
|
Rb,c | P valuec | |||
|---|---|---|---|---|---|---|
| 0 | 3 | 12 | 24 | |||
| CD4+ CD25+ | 9.2 ± 4.6 | 11.9 ± 2.3 | 5.4 ± 1.2 | 4.4 ± 1.1 | −0.614 | <0.0001 |
| CD4+ CD28+ | 86.7 ± 2.6 | 90.8 ± 2.8 | 97.2 ± 0.7 | 93.0 ± 2.2 | 0.415 | 0.0141 |
| CD4+ CD69+ | 9.3 ± 5.9 | 16.2 ± 2.6 | 2.6 ± 1.5 | 1.7 ± 0.9 | −0.649 | <0.0001 |
| CD4+ HLA-DR+ | 13.2 ± 3.0 | 21.4 ± 3.7 | 11.0 ± 4.1 | 8.7 ± 4.7 | −0.475 | 0.005 |
| CD4+ Fas+ | 41.0 ± 13.2 | 85.4 ± 7.6 | 61.0 ± 7.2 | 35.1 ± 22 | −0.166 | 0.3252 |
| CD4+ CD49d+ | 57.8 ± 17.0 | 69.8 ± 7.1 | 51.3 ± 10.0 | 34.7 ± 6.7 | −0.488 | 0.0039 |
| CD8+ CD25+ | 2.2 ± 1.2 | 3.4 ± 1.5 | 1.9 ± 1.2 | 2.2 ± 0.8 | 0.006 | 0.9724 |
| CD8+ CD28+ | 68.6 ± 12.7 | 65.6 ± 6.4 | 65.6 ± 18.3 | 74.3 ± 2.4 | 0.315 | 0.0624 |
| CD8+ CD69+ | 13.7 ± 6.6 | 19.8 ± 8.2 | 16.2 ± 10.1 | 11.6 ± 1.2 | −0.255 | 0.1321 |
| CD8+ HLA-DR+ | 16.1 ± 8.4 | 20.7 ± 12.1 | 22.9 ± 11.1 | 11.8 ± 6.2 | −0.154 | 0.3609 |
| CD8+ Fas+ | 43.2 ± 10.8 | 85.0 ± 7.7 | 66.1 ± 17.7 | 54.8 ± 2.6 | 0.070 | 0.6768 |
| CD8+ CD49d+ | 76.5 ± 12.5 | 82.1 ± 16.9 | 73.7 ± 20.8 | 67.7 ± 14.0 | −0.269 | 0.1109 |
a
Data points included 0, 1, 2, 3, 4, 8, 12, 20, and 24 weeks after SIV infection.
b
Spearman rank correlation for changes in fraction of cells expressing the indicated molecule with time after SIV infection.
c
R and P values calculated from all data points in the first 6 months after intrarectal SIVmac239 inoculation of four rhesus macaques.