Table 4. The association of CEA and CA125 with AE.

Variables	Categorical						Continuous
	Model 1			Model 2			Model 1			Model 2
	HR (95% CI)	P value		HR (95% CI)	P value		HR (95% CI)	P value		HR (95% CI)	P value
CEA	2.66 (1.51–4.69)	0.001		2.00 (1.12–3.59)	0.02		2.10 (1.49–2.95)	<0.001		1.77 (1.22–2.56)	0.003
CA125	2.12 (1.23–3.64)	0.007		1.44 (0.79–2.65)	0.24		1.50 (1.12–1.99)	0.006		1.24 (0.89–1.72)	0.21

Model 1: crude; Model 2: adjusted for DLCO% pred., age, pulmonary hypertension, honeycombing, emphysema. AE, acute exacerbation; CA125, carbohydrate antigen 125; CEA, carcinoembryonic antigen; CI, confidence interval; HR, hazard ratio; DLCO% pred., percent predicted for diffusion capacity of the lung for carbon monoxide.