Table 3.

Associations of multiple sclerosis base variants with cross-sectional outcome measures

Variant (minor allele)	Call rate	MAF	Outcome measure	β (SE)	P-value
rs7758683 (T)	0.96	0.23	White matter lesion volume at 30 years, ml	−7.2 (3.4)	0.036*
rs73091975 (G)	0.96	0.15	ARMSS at 14 years in whole group	−2.1 (0.8)	0.012*
			ARMSS at 14 years in multiple sclerosis–only subgroup	−2.7 (0.8)	3.9 × 10−3**
			GMF at 30 years in multiple sclerosis–only subgroup, %	0.9 (0.4)	0.039*

Beta-coefficients (β) and P-values obtained from linear regression models assessing associations of variant allele dosage with outcome measures were adjusted for age, sex, DMT use and smoking history.

MAF, minor allele frequency.

^* P < 0.05.

^**Bonferroni correction for number of timepoints and outcomes (0.05/12) = P  < 4.2 × 10⁻³.