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. 2024 Dec 12;34(1):e5254. doi: 10.1002/pro.5254

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© 2024 The Author(s). Protein Science published by Wiley Periodicals LLC on behalf of The Protein Society.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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CCS distributions of (a) unbound AR‐TAU5, (b) EPI‐001‐bound AR‐TAU5 charge states. The black box highlights an intermediate conformational space, that is more highly populated by AR‐TAU5 in the presence of EPI‐001 via elongation of charge states 7+ and 8+ and compaction of 9+ and 10+. The height of each CCS distribution corresponds to the relative intensity of the corresponding peak in the mass spectrum shown in Figure 3b, with the bottom panel being magnified 3x due to the low signal intensity for the protein:molecule complex.