Scheme 1. Synthetic Scheme for the Synthesis of Boc-Protected Guanidine-Functionalized Monomer through: (a) Esterification of Cholic Acid (I) with HEMA (II) to Form (2-Methacryloyloxy) Ethyl Cholate (MAECA); (b) Subsequent Esterification with Bromoacetyl Bromide (III) to Form Tri-Substituted Bromo-Ended (2-Methacryloyloxy) Ethyl Cholate (Tri-Br-MAECA); and (c) Substitution with Thiol (IV) to Yield Tri-Substituted Boc-Protected Guanidine-Capped (2-Methacryloyloxy) Ethyl Cholate (Tri-Boc-Gua-MAECA).
